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Search Results for " Breast cancer resistance protein "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
TQ0186	Ko 143		BCRP , ABC
	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).		BCRP , ABC
T3581	KS176		Potassium Channel , BCRP
	KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.		Potassium Channel , BCRP
T4595	YHO-13177	YHO 13177,YHO13177	BCRP
	YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.		BCRP
T38400	Triclabendazole sulfoxide	TCBZ-SO	BCRP , Parasite
	Triclabendazole sulfoxide (TCBZ-SO) is a main plasma metabolite of Triclabendazole. Triclabendazole sulfoxide inhibits membrane transporter ABCG2/BCRP and exhibits anti-parasite effects.		BCRP , Parasite
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T4337	PCI 29732	PCI29732,PCI-29732	Others , BCRP , BTK
	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.		Others , BCRP , BTK
T83892	33-BCRP Inhibitor	33-Breast Cancer Resistance Protein Inhibitor
	33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantro...
T2657	Elacridar	GW0918,GW120918,GF120918,GG918	BCRP , P-gp
	Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.		BCRP , P-gp
T6200	Ledipasvir	GS-5885	HCV Protease , SARS-CoV
			HCV Protease , SARS-CoV
T10490	(S)-ML753286		Others
	(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter).		Others
T37685	CAY10719	CAY10719
	CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPas...
T14340	Atiratecan	TP300	Others
	Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. A...		Others
T14945	CH-0793076	TP3076	Topoisomerase
	CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisome...		Topoisomerase
T73356	Ac32Az19
	Ac32Az19 is a potent, non-toxic, and highly selective inhibitor of Breast Cancer Resistance Protein (BCRP), demonstrating an EC50 of 13 nM in BCRP-overexpressed HEK293/R2 cells.
T73672	CH-0793076 TFA
	CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC 50 of 2.3 μM. CH-0793076 TFA is efficacious against cells ex...
T72861	(6R)-ML753286
	'(6R)-ML753286, an isomer of ML753286, is an orally active, selective Breast Cancer Resistance Protein (BCRP) inhibitor, demonstrating an IC50 of 0.6 μM. It exhibits high permeability and low to medium clearance in roden...
T36807	Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
	Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-med...

Compounds

Target: Potassium Channel, BCRP

YHO-13177

T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Triclabendazole sulfoxide

T38400

Synonym: TCBZ-SO

Target: BCRP, Parasite

Zamicastat

T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

PCI 29732

T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

33-BCRP Inhibitor

T83892

Synonym: 33-Breast Cancer Resistance Protein Inhibitor

Target:

Elacridar

T2657

Synonym: GW0918,GW120918,GF120918,GG918

Target: HCV Protease, SARS-CoV

Target: Topoisomerase

Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)

T36807

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T15355	Fumitremorgin C	12α-Fumitremorgin C	BCRP , Antibacterial , Antibiotic , ABC
			BCRP , Antibacterial , Antibiotic , ABC
TN3150	6,8-Diprenylnaringenin	Senegalensin,Lonchocarpol A	BCRP , ABC
			BCRP , ABC
T3208	Brevianamide F	Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP , PI3K , Antibacterial
	Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess interesting breast cancer resistance protein inhibitory acti...		BCRP , PI3K , Antibacterial
TN5190	Tryprostatin A		Topoisomerase , Antifection
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase.		Topoisomerase , Antifection

天然物製品

Fumitremorgin C

T15355

Synonym: 12α-Fumitremorgin C

Target: BCRP, Antibacterial, Antibiotic, ABC

6,8-Diprenylnaringenin

TN3150

Synonym: Senegalensin,Lonchocarpol A

Target: BCRP, ABC

Brevianamide F

T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

Tryprostatin A

TN5190

Synonym:

Target: Topoisomerase, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03156	VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His)	Mouse,Rat	HEK293
	Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-01007	VEGFC Protein, Human, Recombinant (His)	Human	HEK293
	Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-00971	CEACAM6 Protein, Human, Recombinant (His)	Human	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-05850	CEACAM6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-03155	VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc)	Mouse,Rat	HEK293
	Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotei...
TMPY-06758	CEACAM6 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-05460	CEACAM6 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-06760	CEACAM6 Protein, Human, Recombinant (hFc)	Human	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It ...
TMPY-04001	Angiopoietin-like 7 Protein, Canine, Recombinant (His)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04000	Angiopoietin-like 7 Protein, Canine, Recombinant (hFc)	Canine	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...
TMPY-04004	Angiopoietin-like 7 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. Obesity increases the l...